Наношероховатость и микрошероховатость имплантатов: аспекты химической и биологической безопасности
Аннотация
В обзоре впервые рассмотрены параметры нано- и микрошероховатости поверхности имплантируемых материалов, конструкций и устройств с точки зрения химической безопасности. Обсуждаются проблемы, возникающие при использовании материалов, химически опасных для организма (например, цитотоксичных, генотоксичных, аллергенных, тератогенных, мутагенных), и легко эродируемых текстур имплантируемых материалов с высокой шероховатостью. Указывается на риск включения элементов имплантируемых материалов в реакционно-диффузионные схемы гистогенеза / морфогенеза регенерируемой ткани или органа. Дается представление о различии цитоэлектрохимического отклика на металлические и полупроводниковые структуры имплантата. Приводятся сведения о нарушениях в процессе гистогенеза и регенерации при использовании неоптимальных технологий и протоколов обработки поверхности имплантатов, таких, в частности, как пескоструйная, абразивная обработка и некоторые типы травления (в том числе, плазменное травление). Кратко излагаются биомиметические методы повышения биосовместимости имплантатов. Особое внимание уделяется оптимизации шероховатости поверхности имплантата. Это включает как классические параметры (Ra, Rq, Rz, Rt, Rsk), так и текстурные характеристики (Sm). Также изучается влияние состава имплантата, в частности, использование биогенных и биоподобных покрытий.
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