Toxicological and hygienic studies of the technical product cyazofamide
Abstract
In order to prevent the adverse effects of the use of plant protection products, to scientifically substantiate risks in conditions of actual use and to develop measures for safe handling, it is necessary to conduct toxicological and sanitary-chemical studies of new formulations, assess the risk in their use and hygienic regulation of new active substances, which will minimize negative impact on public health, the environment and the associated economic damage. It has been shown that the technical product cyazofamide 95% belongs to low-hazard substances in terms of acute toxicity with oral and transdermal routes of intake, does not have an irritating, sensitizing and cumulative effect.
References
Plant protection products. http://selhozhimiya.net/ (accessed: 24. 03.2022).
State register of plant protection products and fertilizers permitted for use on the territory of the Republic of Belarus. https://ggiskzr.by/reestr/ (accessed: 24.03.2022).
Instruction 2.2.3.10–24–81–2006. Requirements for the state sanitary and hygienic examination of plant protection products (approved by the Ministry of Health of the Republic of Belarus on December 24, 2006). Minsk: Ministry of Health, 2006. 17 p (in Russ).
Guidelines for the hygienic assessment of new pesticides No. 4263-87 (approved by the Ministry of Health of the USSR on March 13, 1987). Kyiv, 1988 (in Russ).
GOST 32644-2014. Interstate standard. Test methods for the effects of chemical products on the human body. https://docs.cntd.ru/document/1200115815 (accessed: 24.03.2022).
Instruction 1.1.11-12-35-2004. Requirements for the organization of experimental studies for the primary toxicological assessment and hygienic regulation of substances (approved by the Ministry of Health of the Republic of Belarus on 14.12.2004). Minsk: Ministry of Health, 2004. 43 p (in Russ).
Coast, E. A. (1975). Handbook of Clinical Laboratory Research. M.: Medicine.
Kamyshnikov, V. S. Handbook of clinical and biochemical laboratory diagnostics. https://balka-book.com/files/2017/09_05/12_38/u_files_store_3_413182.pdf. (accessed: 03.24.2022).
Rokitsky P.F. (1964). biological statistics. Minsk: Higher School, 328 p (in Russ).
TСP (Technical Сode of Practice) 125-2008. Good laboratory practice. (approved by the Decree of the Ministry of Health of the Republic of Belarus on March 28, 2008 No. 56). Minsk, 2008. 35 p.
GOST (State Standart) 12.1.007-76 SSBT. Harmful substances. Classification and general safety requirements (in Russ).
Uniform sanitary and epidemiological and hygienic requirements for products (goods) subject to sanitary and epidemiological supervision (control) (approved by the Decision of the Customs Union Commission dated May 28, 2010 No. 29). http://www.eurasiancommission.org/ru/act/texnreg/depsanmer/sanmeri/Pages/P2_299.aspx. (accessed 03.24.2022).
Copyright (c) 2022 Svetlana Yu. Petrova, and Tatyana N. Gomolko
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
