Toxicological and hygienic studies with risk assessment when using a herbicide, containing diflufenican, metribuzin and florasulam in the conditions of the agro-industrial complex

Abstract

The herbicide containing diflufenican, metribuzin and florasulam as active ingredients, according to the results obtained, is classified as hazard class 4 in terms of acute toxicity when administered intragastrically and applied to the skin, and inhalation toxicity is classified as hazard class 3. It has been established that the drug does not irritate the skin of rats (class 4), has a slight irritant effect on the mucous membranes of the eyes of rabbits (class 3B), does not have a sensitizing effect (class 4), and is classified as class 4 in terms of cumulative action. Based on a comprehensive assessment, taking into account the limiting indicator (inhalation toxicity), the herbicide containing diflufenican, metribuzin and florasulam as active ingredients is classified as a moderately hazardous substance (hazard class 3) in accordance with the hygienic classification. For the production conditions of the drug in accordance with GOST 12.1.007-76 SSBT, the studied herbicide is assigned to the 2nd hazard class (highly hazardous substances). The content of the active ingredients of the drug in the air of the working area and on the skin, taking into account the risk of inhalation and dermal exposure (for a tanker operator – 0,2778; for a tractor driver – 0,3027 with an allowable < 1), allowed us to conclude that when given technology and regulations, as well as subject to safety measures, the conditions for using the drug comply with hygienic requirements.