Current issues of the efficacy and safety of quaternary ammonium compounds when used in antiseptic and disinfectant agents ‒ a review
Abstract
The publication summarizes and analyzes current data from various literary sources on the issue of the effectiveness and safety of using quaternary ammonium compounds in biocidal agents. Using ionic liquids and quaternary phosphonium compounds as examples, important aspects of the development and synthesis of new antimicrobial compositions as alternative chemical agents with high target efficiency and a lower degree of potential toxicity are discussed. The information presented in the article indicates the need to reconsider the practice of widespread use of QACs in biocidal products, closer attention from regulatory authorities during testing and registration of new disinfectants and antiseptics based on QACs, and the importance of additional targeted research for an objective assessment of the problem.
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