Hydroxyapatite as a Mineral Matrix for Antibacterial Substances
Abstract
A procedure has been developed for preparing a hydroxyapatite-based matrix with differently structured particles intended for manufacturing compositions for therapeutic and prophylactic use. Complexes of iron(III) and manganese(III) with tetraphenylporphyrin, known for their antibacterial activity, are used as modifying agents. The process of immobilization of metal complexes on the hydroxyapatite matrix proceeds under the action of ultrasonic field. The composition based on nanosized hydroxyapatite and tetraphenylporphyrin metal complexes is found to have a higher antibacterial activity than the composition based on the microorganized hydroxyapatite particles. The results of preliminary biomedical assays indicate potential benefits of using the modified hydroxyapatite-based composition for medical applications.
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